The complex physiological process of haemostasis is controlled by precise balance between body’s thrombogenic and antithrombogenic system. An imbalance between them causes patient to be more likely to have thrombosis. Many patients have haematological disorders that interfere with a proper clot formation or take medications to alter their coagulation status and place them at an increased risk for postoperative haemorrhage. Therefore prior to using any pharmacological treatments it is necessary to understand the physiology of the same. In order to successfully execute surgery/ or interventional procedures, coagulation altering therapy should be based on patient ‘s unique condition and surgical related concerns-simply identifying risks and adhering to consensus guidelines. Taking into account the choice of alternate methods, Anti coagulant dosage recommendation from manufacturer should be followed. In order to achieve best result haematologist consultation is crucial.