Tab Article

For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as a valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling, and assay, qNMR can be utilized.

Separation techniques such as high-performance liquid chromatography, gas chromatography, superfluid chromatography, and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve analytical problems often resulting in insufficient methods. Nevertheless, such methods find their way into international pharmacopeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis.

Besides the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid-phase NMR spectroscopy for the characterization of drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples.

• Combines theory, techniques, and concrete applications—all of which closely resemble the laboratory experience

• Considers international pharmacopeias, addressing the concern for licensing

• Features the work of academics and researchers, appealing to a broad readership